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Govindaraj, Jayamathi
- Xylene–A Potential Health Hazard―A Review
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Authors
Bhaskaran Sathyapriya
1,
Govindarajan Sumathy
1,
Balasubramanian Chandrakala
1,
Jinu Merlin Koshy
2,
Jayamathi Govindaraj
3,
Kesavaram Padmavathy
4
Affiliations
1 Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
2 Department of Anatomy, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
3 Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
4 Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
1 Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
2 Department of Anatomy, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
3 Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
4 Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 12 (2019), Pagination: 2251-2255Abstract
Xylene is a colorless liquid with the molecular formula C8H10. A flammable, non-explosive aromatic hydrocarbon, xylene consists of a benzene ring with two attached methyl groups. Xylene occurs naturally in petroleum and small amounts occur in gasoline and jet fuel. It is used in paints, inks, glues and other products. The population at large is expected to be exposed primarily to mixed xylenes, rather than to any of the xylene isomers individually. The general population can be exposed to xylene via inhalation of indoor and workplace air, automobile exhaust, tobacco smoke, xylene-containing solvents, ingestion of contaminated drinking water, and dermal absorption of xylene containing products. Xylene is released primarily from industrial sources. The existence of hazards in the workplace has raised concerns about the potential of these substances for adverse effects.Keywords
Xylene, Dyspnoea, Occupational.- Occupational Hazards of Xylene and its Preventive Measures
Abstract Views :514 |
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Authors
Govindarajan Sumathy
1,
Bhaskaran Sathyapriya
1,
Balasubramanian Chandrakala
1,
Jinu Merlin Koshy
2,
Jayamathi Govindaraj
3,
Kesavaram Padmavathy
4
Affiliations
1 Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
2 Department of Anatomy, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
3 Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
4 Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
1 Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
2 Department of Anatomy, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
3 Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
4 Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 12 (2019), Pagination: 2260-2264Abstract
Xylene is an aromatic hydrocarbon known for its wide usage in tissue processing, staining and cover slipping in the histology laboratory. The hazards of xylene are well documented, making it a potential occupational hazard for the histopathological technicians. As every other profession became cautious of the occupational hazards, the very speciality that identifies the illnesses became one of the last to become aware and remedy its own hazards. This article aims to discuss the toxicity of xylene and safety measures to counteract the hazards of xylene.Keywords
Toxicity of Xylene, Xylene Substitutes, Xylene.- Phytochemical Investigation and Antimicrobial Activity of Root Extracts of Withania Somnifera (L.) Dunal. against Drug- Resistant Bacterial Pathogens
Abstract Views :495 |
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Authors
Thirunavukkarasu Umaarasu
1,
Kesavaram Padmavathy
1,
Dharmalingam Thirunavukkarasu
2,
Jayamathi Govindaraj
3,
S. V. Rajesh
4,
Gnanendra Shanmugam
5
Affiliations
1 Department of Microbiology, Research Laboratory for Oral & Systemic Health, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, IN
2 Department of Microbiology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, IN
3 Department of Botany, Ramakrishna Mission Vivekanandha College, Mylapore, Chennai, Tamilnadu, IN
4 Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu,, IN
5 Department of Biotechnology, Yeungnam University, Gyeongsan, KP
1 Department of Microbiology, Research Laboratory for Oral & Systemic Health, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, IN
2 Department of Microbiology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, IN
3 Department of Botany, Ramakrishna Mission Vivekanandha College, Mylapore, Chennai, Tamilnadu, IN
4 Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu,, IN
5 Department of Biotechnology, Yeungnam University, Gyeongsan, KP
Source
Indian Journal of Public Health Research & Development, Vol 10, No 12 (2019), Pagination: 2265-2270Abstract
With the emergence of multidrug resistance among clinical bacterial pathogens there is a growing need for the development of herbal alternatives for the effective therapeutic management of bacterial infections. Plants and plants products have long been used in traditional folk medicine worldwide. Hence this study was designed to test the antimicrobial efficacy of Withania somnifera L. Dunal. (ischolar_main) against drug resistant bacterial pathogens. Extracts of W. somnifera (L.) Dunal (ischolar_main) was prepared by cold percolation method. Antimicrobial activity of different solvent extracts of W. somnifera (L.) Dunal. (ischolar_main) was studied against drug-resistant clinical isolates of Gram-positive cocci (vancomycin resistant Enterococcus faecalis and Methicillin resistant Staphylococcus aureus) and Gram-negative bacilli (ESBL Escherichia coli and Pseudomonas aeruginosa). The standard strains of ATCC 25922 E. coli, ATCC 25923 S. aureus, ATCC 27853 P. aeruginosa, and ATCC 29212 E. faecalis were used as controls. Antibacterial activities of extracts were evaluated using agar well diffusion method. Minimum inhibitory concentration was determined by microbroth dilution method. All the extracts (methanol, ethanol, acetone and chloroform) were inhibitory to gram positive bacteria tested. Nevertheless,inhibitory effect waspronounced in the methanol and ethanol extract, against gram negative bacteria (Both ATCC and clinical strains).Further based on the phytochemical and GC-MS analysis, it could be speculated that the antibacterial activity exhibited by the methanol extract of W. somnifera ischolar_main could be attributed to the presence of phenolic compounds, flavonoids, steroids and terpenes.Keywords
Antibacterial Efficacy, ESBL, E. coli, Withania somnifera, MRSA, VRE, Pseudomonas aeruginosa.- Role of Free Radicals in Cellular Signaling: A Review
Abstract Views :109 |
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Authors
Jayamathi Govindaraj
1,
Keerthidaa Govindaraj
2,
S. Raghavendra Jayesh
3,
Padmavathy Kesavaram
4,
U. Vidyarekha
5
Affiliations
1 Professor, Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, IN
3 Professor, Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (BIHER) Pallikaranai, IN
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College and Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, IN
1 Professor, Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, IN
3 Professor, Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (BIHER) Pallikaranai, IN
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College and Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 2799-2802Abstract
Reactive oxygen species (ROS) were once considered to be deleterious agents, contributing to a vast range of pathologies. Both their damaging and beneficial effects are initiated when they target distinct molecules and consequently begin functioning as part of complex signal-transduction pathways. The recognition of ROS as signaling mediators has driven a wealth of research into their roles in both normal and pathophysiological states. The present review assesses the outline of current perspectives on redox-signaling mechanisms.Keywords
Reactive Oxygen Species, Oxidative Stress, Nitric Oxide.- A Review on Visfatin/Nicotinamide Phosphoribosyltransferase/Pre-B Cell Colony-Enhancing Factor
Abstract Views :143 |
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Authors
Jayamathi Govindaraj
1,
Keerthidaa Govindaraj
2,
S. Raghavendra Jayesh
3,
Padmavathy Kesavaram
4,
U. Vidyarekha
5
Affiliations
1 Professor, Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, IN
3 Professor, Department of Prosthodontics, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, (BIHER), Pallikaranai, IN
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College & Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, IN
1 Professor, Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, IN
3 Professor, Department of Prosthodontics, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, (BIHER), Pallikaranai, IN
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College & Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, IN